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L L Chen Selected Research

2- ((1- (3,5- dichlorobenzenesulfonyl)pyrrolidine- 2- carbonyl)amino)- 4- (4- methyl- 2- (methyl- (2- (4- (3- o- tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acid

2/2005Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties.
6/2003An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis.

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L L Chen Research Topics

Disease

5Neoplasms (Cancer)
06/2021 - 11/2006
4Type 2 Diabetes Mellitus (MODY)
01/2016 - 11/2007
3Hypertension (High Blood Pressure)
05/2022 - 10/2015
3Body Weight (Weight, Body)
01/2019 - 02/2016
2Heart Failure
05/2022 - 08/2014
2Ventricular Remodeling
09/2020 - 08/2014
2Inflammation (Inflammations)
04/2020 - 05/2000
2Bone Resorption
06/2019 - 07/2001
2Periodontitis
06/2019 - 12/2017
2Diabetic Retinopathy (Retinopathy, Diabetic)
10/2018 - 03/2009
2Gestational Trophoblastic Disease (Trophoblastic Neoplasms, Gestational)
06/2018 - 06/2017
2Virus Diseases (Viral Diseases)
04/2017 - 11/2007
2Renal Cell Carcinoma (Grawitz Tumor)
08/2016 - 02/2016
2Obesity
08/2016 - 02/2016
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
02/2005 - 06/2003
1Tendinopathy (Tendonitis)
03/2022
1Graves Disease (Basedow Disease)
12/2021
1Heart Diseases (Heart Disease)
12/2021
1Hyperthyroidism
12/2021
1Cardiomegaly (Heart Hypertrophy)
11/2021
1Hypertrophy
11/2021
1Adenocarcinoma
07/2021
1Cardiomyopathies (Cardiomyopathy)
09/2020
1Snoring
05/2020
1Cholangitis
04/2020
1Necrosis
04/2020
1Hepatitis
04/2020
1Interstitial Lung Diseases (Interstitial Lung Disease)
10/2019
1Myositis (Idiopathic Inflammatory Myopathies)
10/2019
1Connective Tissue Diseases (Connective Tissue Disease)
10/2019
1Periodontal Diseases (Periodontal Disease)
05/2019
1Weight Loss (Weight Reduction)
01/2019
1Stroke (Strokes)
09/2018
1Neoplasm Metastasis (Metastasis)
06/2018
1Atrial Fibrillation
05/2018
1Ductal Carcinoma
03/2018
1Granulomatous Mastitis
03/2018
1Dermatitis
04/2017
1Infections
04/2017
1Ventilator-Associated Pneumonia
03/2017
1Asthma (Bronchial Asthma)
02/2017
1Allergic Rhinitis
02/2017
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2017
1Chronic Obstructive Pulmonary Disease (COPD)
11/2016
1Colorectal Neoplasms (Colorectal Cancer)
07/2016

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
05/2019 - 11/2007
4Blood Glucose (Blood Sugar)IBA
01/2019 - 06/2012
4Triglycerides (Triacylglycerol)IBA
08/2016 - 11/2007
3CholesterolIBA
01/2019 - 02/2016
3HDL CholesterolIBA
08/2016 - 10/2015
3LDL CholesterolIBA
08/2016 - 10/2015
2AldosteroneIBA
12/2021 - 08/2014
2MicroRNAs (MicroRNA)IBA
12/2021 - 11/2021
2AntibodiesIBA
07/2021 - 10/2019
2CytokinesIBA
06/2019 - 12/2017
2TeaIBA
09/2018 - 07/2016
2Methotrexate (Mexate)FDA LinkGeneric
06/2018 - 06/2017
2LipidsIBA
08/2016 - 02/2016
2Glucose (Dextrose)FDA LinkGeneric
03/2009 - 11/2007
22- ((1- (3,5- dichlorobenzenesulfonyl)pyrrolidine- 2- carbonyl)amino)- 4- (4- methyl- 2- (methyl- (2- (4- (3- o- tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acidIBA
02/2005 - 06/2003
1Protons (Proton)IBA
03/2022
1Biomarkers (Surrogate Marker)IBA
12/2021
1AngiotensinsIBA
12/2021
1Chymosin (Rennin)IBA
12/2021
1Circular RNAIBA
11/2021
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
06/2021
1Phosphatidylinositols (Phosphatidylinositol)IBA
06/2021
1TensinsIBA
06/2021
1omega-Chloroacetophenone (Mace)IBA
09/2020
1ORALIT (ORS)IBA
05/2020
1Phosphotransferases (Kinase)IBA
04/2020
1Immune Checkpoint InhibitorsIBA
04/2020
1Tyrosine (L-Tyrosine)FDA Link
04/2020
1Interleukin-17 (Interleukin 17)IBA
06/2019
1Interferon-gamma (Interferon, gamma)IBA
06/2019
1oxidized low density lipoproteinIBA
01/2019
1Fluorescein (Funduscein)FDA LinkGeneric
10/2018
1Dactinomycin (Actinomycin)FDA LinkGeneric
06/2018
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2018
1Etoposide (VP 16)FDA LinkGeneric
06/2018
1Vincristine (Oncovin)FDA LinkGeneric
06/2018
1NG-Nitroarginine Methyl Ester (L-NAME)IBA
05/2018
1Immunoglobulin M (IgM)IBA
03/2018
1SugarsIBA
12/2017
1Etanercept (Enbrel)FDA Link
04/2017
1Immunoglobulin G (IgG)IBA
04/2017
1Trichloroethylene (Trichloroethene)IBA
04/2017
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
04/2017
1Therapeutic UsesIBA
02/2017
1Charcoal (Charbon)IBA
11/2016
1Coal (Coals)IBA
11/2016
1Natural Gas (Gas, Natural)IBA
11/2016
1SmokeIBA
11/2016
1SP6616IBA
01/2016

Therapy/Procedure

3Drug Therapy (Chemotherapy)
06/2018 - 11/2006
2Therapeutics
05/2022 - 04/2020
2Nephrectomy
08/2016 - 02/2016
1Percutaneous Coronary Intervention
09/2020
1Ligation
12/2017
1Tracheotomy
03/2017